The global downstream processing market size is anticipated to around USD 40.1billion by 2026, this market is anticipated to grow with 14.0% CAGR during the forecast time period. Surge in acceptanceand adoption of biotech processes in the agricultural, pharmaceutical, and bio-services industriesis anticipated to boot the market over the forthcoming years.
The global downstream processing market is segmented into four major segment named product, technique, application, and region. On the basis of product the downstream processing market is segmented into chromatography systems, filters, evaporators, centrifuges, dryers and others. On the basis of the technique the global downstream processing market is segmented into cell disruption, solid-liquid separation (filtration, centrifugation) concentration (evaporation, membrane filtration), and purification by chromatography and formulation. These solid-liquid separation are further bifurcated into filtration, and centrifugation, and the concentration is also further segmented evaporation, and membrane filtration. On the basis of application, the downstream processing market is segmented into antibiotic production, hormone production, antibodies production, enzyme production, and vaccine production. On the basis of region the global downstream processing market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.
Main market participantsdelivers safe and integrated chromatography solutions that work efficiently throughout all steps of a bioprocess. In current years, key vendors have established technologically competent systems that address emerging needs of the industry to accomplish state-of-the-art chromatography steps throughout manufacturing of bio-therapeutics. Such as, single-use chromatography is single of the most important inventions of the biopharmaceutical business.
Single-use chromatography eradicates the need for large-scale chromatography columns, resin storage, column packing,and storage of packed columns. The technology has also led to reduction in water and chemicals for cushion to as much as 80.0%. This safeguardsaugmented productivity and competence of bioprocess in less time and with abridged labor.
Filter manufacturers have been emergingprogressive filters with high performance due to growing need for viral clearance. Viruses can brutally damage an entire process stream. There are numerous micro and ultra-filters commercially accessible in the market. A few instances of the same comprise of Viresolve filters from Merck Millipore,Planova virus removal filters from Asahi-Kasei, and Virosart brand from Sartorius Stedim Biotech.
Also, to virus clearance, sterile filtration is also deployment for removal of certain antibiotic resistant bacterial species for instance Mycoplasma. Filters deployment for this purpose comprise of Millipore Express from Merck, Nalgene PES filters and Fluorodyne from Pall Corporation (Danaher).
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Antibodies are one of the most major modalities obtainable by the biopharmaceutical sector today. This accomplishment is due to establishment of robust manufacturing platforms that generate high titers for monoclonal antibodies in mammalian cell cultures.
Also, development of certain new methods in bioprocessing of antibodies have additionalincreased the market. These new methods comprise ofconstant alternative expression systems, bio manufacturing, and non‐chromatographic separation formats.
Furthermore, as antibiotic resistance is on increase, there is asurge in need for growth of antibodies that act against resistant strains. This, in turn, is growing the need for downstream processing for antibody production at industrial scale.
North America captures the largest the global downstream processing market in 2018. The development of the region can be attributed to augmented focus of government bodies on the growth of the biotechnology industry, increasing healthcare expenditure, and occurrence of adequate infrastructure for development and growth of bioprocessing industries.Due to recent progressions, there is a considerable increase in sales of biotechnology products in the region. Consequently, continual innovations in the biotechnology sector are possible to deliver plenty development opportunities to the regional market during the forecast timeframe.
The key players operating in the global downstream processing market areGeneral Electric Company (GE Healthcare), Thermo Fisher Scientific Inc., Merck KGaA (Merck Millipore), Sartorius Stedim Biotech S.A., and Danaher Corporation. Some other players catering to the market are Dover Corporation (CPC (Colder Products Co.)), Repligen, Boehringer Ingelheim International GmbH, 3M Company, Eppendorf AG, Corning Corporation, Ashai Kasei, Lonza Group Ltd, and Ferner PLC. These market player are investing massive wealth to transform the product line as the rivalry in the market is increasing with rapid pace. Likewise, with varying technology the need for better technology infrastructures are rising, so cater the need of the customers, market participants are continuously inventing new products.